› 2m7q

Solution NMR

Solution structure of TAX1BP1 UBZ1+2

Released:
DOI: 10.2210/pdb2m7q/pdb
PDB entry 2m7q coloured by chain, ensemble of 20 models, front view.
PDB entry 2m7q coloured by chain, ensemble of 20 models, side view.
PDB entry 2m7q coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The structure of TAX1BP1 UBZ1+2 provides insight into target specificity and adaptability.
Ceregido MA, Spínola Amilibia M, Buts L, Rivera-Torres J, Garcia-Pino A, Bravo J, van Nuland NA
J Mol Biol 426 674-90 (2014)
PMID: 24239949

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183212 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tax1-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 69 amino acids
Theoretical weight: 8.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86VP1 (Residues: 725-789; Coverage: 8%)
Gene names: PRO0105, T6BP, TAX1BP1
Sequence domains: Autophagy receptor zinc finger-C2H2 domain
Structure domains: Double Stranded RNA Binding Domain

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection.
Shariq et al. (2023)
2 more