› 2m84

Solution NMR

Structure of 2'F-RNA/2'F-ANA chimeric duplex

Released:
DOI: 10.2210/pdb2m84/pdb
PDB entry 2m84 coloured by chain, ensemble of 10 models, front view.
PDB entry 2m84 coloured by chain, ensemble of 10 models, side view.
PDB entry 2m84 coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Backbone FC-H···O hydrogen bonds in 2'F-substituted nucleic acids.
Martin-Pintado N, Deleavey GF, Portella G, Campos-Olivas R, Orozco M, Damha MJ, González C
Angew Chem Int Ed Engl 52 12065-8 (2013)
PMID: 24115468

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113103 (preferred)
Entry contents:
1 distinct DNA/RNA hybrid molecule
Macromolecule:
2'F-RNA/2'F-ANA CHIMERIC DUPLEX Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.88 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
6 modified residues:
Ligand CFZ 4 x CFZ
Ligand GF2 4 x GF2
Ligand AF2 4 x AF2
Ligand TAF 4 x TAF
Ligand CFL 4 x CFL
Ligand GFL 4 x GFL

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

4 review citations

Synthesis and biological applications of fluoro-modified nucleic acids.
Guo et al. (2017)
3 more

1 mention without citation

The structural diversity of artificial genetic polymers.
Anosova et al. (2016)