› 2m8o

Solution NMR

NMR assignment and structure of a peptide derived from the membrane proximal external region of HIV-1 gp41 in DPC

Released:
DOI: 10.2210/pdb2m8o/pdb
PDB entry 2m8o coloured by chain, ensemble of 20 models, front view.
PDB entry 2m8o coloured by chain, ensemble of 20 models, side view.
PDB entry 2m8o coloured by chain, ensemble of 20 models, top view.
Source organism: Human immunodeficiency virus type 1 (SC ISOLATE)
Primary publication:
Structure and immunogenicity of a peptide vaccine, including the complete HIV-1 gp41 2F5 epitope: implications for antibody recognition mechanism and immunogen design.
Serrano S, Araujo A, Apellániz B, Bryson S, Carravilla P, de la Arada I, Huarte N, Rujas E, Pai EF, Arrondo JLR, Domene C, Jiménez MA, Nieva JL
J Biol Chem 289 6565-6580 (2014)
PMID: 24429284

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138823 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 28 amino acids
Theoretical weight: 3.66 KDa
Source organism: Human immunodeficiency virus type 1 (SC ISOLATE)
Expression system: Not provided
UniProt:
  • Canonical: P05878 (Residues: 656-683; Coverage: 3%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 55%
Refinement method: torsion angle dynamics, molecular dynamics
Expression system: Not provided

Quick links

Citations

1 review citation

The Hard Way towards an Antibody-Based HIV-1 Env Vaccine: Lessons from Other Viruses.
Ringel et al. (2018)
14 other articles

4 mentions without citation

The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region.
Apellániz et al. (2015)
3 more