› 2m8v

Solution NMR

Solution Structure and Activity Study of Bovicin HJ50, a Particular Type AII Lantibiotic

Released:
DOI: 10.2210/pdb2m8v/pdb
PDB entry 2m8v coloured by chain, ensemble of 20 models, front view.
PDB entry 2m8v coloured by chain, ensemble of 20 models, side view.
PDB entry 2m8v coloured by chain, ensemble of 20 models, top view.
Source organism: Streptococcus equinus
Primary publication:
Type AII lantibiotic bovicin HJ50 with a rare disulfide bond: structure, structure-activity relationships and mode of action.
Zhang J, Feng Y, Teng K, Lin Y, Gao Y, Wang J, Zhong J
Biochem J 461 497-508 (2014)
PMID: 24814218

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182983 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lantibiotic Chain: A
Molecule details ›
Chain: A
Length: 33 amino acids
Theoretical weight: 3.44 KDa
Source organism: Streptococcus equinus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q83ZN8 (Residues: 26-58; Coverage: 57%)
Gene name: bovA
Sequence domains: Type-A lantibiotic

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: molecular dynamics, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The expanding structural variety among bacteriocins from Gram-positive bacteria.
Acedo et al. (2018)
5 more

3 mentions without citation

Antimicrobial Peptides: An Update on Classifications and Databases.
Bin Hafeez et al. (2021)
2 more