› 2ma2

Solution NMR

Solution structure of RasGRP2 EF hands bound to calcium

Released:
DOI: 10.2210/pdb2ma2/pdb
PDB entry 2ma2 coloured by chain, ensemble of 10 models, front view.
PDB entry 2ma2 coloured by chain, ensemble of 10 models, side view.
PDB entry 2ma2 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.
Iwig JS, Vercoulen Y, Das R, Barros T, Limnander A, Che Y, Pelton JG, Wemmer DE, Roose JP, Kuriyan J
Elife 2 e00813 (2013)
PMID: 23908768

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RAS guanyl-releasing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7LDG7 (Residues: 417-497; Coverage: 13%)
Gene names: CDC25L, MCG7, RASGRP2
Sequence domains: EF hand
Structure domains: EF-hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 77%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

8 review citations

RAP1-GTPase signaling and platelet function.
Stefanini et al. (2016)
7 more

1 mention without citation

Modeling of RAS complexes supports roles in cancer for less studied partners.
Engin et al. (2017)