› 2mb3

Solution NMR

Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative

Released:
DOI: 10.2210/pdb2mb3/pdb
PDB entry 2mb3 coloured by chain, ensemble of 10 models, front view.
PDB entry 2mb3 coloured by chain, ensemble of 10 models, side view.
PDB entry 2mb3 coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative.
Chung WJ, Heddi B, Tera M, Iida K, Nagasawa K, Phan AT
J Am Chem Soc 135 13495-501 (2013)
PMID: 23909929

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115604 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA_(5'-D(*TP*TP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*A)-3') Chain: A
Molecule details ›
Chain: A
Length: 24 nucleotides
Theoretical weight: 7.59 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand L2H 1 x L2H
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 39%
Refinement method: DGSA-distance geometry simulated annealing, simulated annealing, molecular dynamics
Expression system: Not provided

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Citations

14 review citations

Ligand Design to Acquire Specificity to Intended G-Quadruplex Structures.
Asamitsu et al. (2019)
13 more

12 mentions without citation

G-Quadruplexes as An Alternative Recognition Element in Disease-Related Target Sensing.
Ida et al. (2019)
11 more