› 2mb7

Solution NMR

Solution structure of MBD3 methylcytosine binding domain

Released:
DOI: 10.2210/pdb2mb7/pdb
PDB entry 2mb7 coloured by chain, ensemble of 20 models, front view.
PDB entry 2mb7 coloured by chain, ensemble of 20 models, side view.
PDB entry 2mb7 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA.
Cramer JM, Scarsdale JN, Walavalkar NM, Buchwald WA, Ginder GD, Williams DC
J Biol Chem 289 1294-302 (2014)
PMID: 24307175

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132095 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methyl-CpG-binding domain protein 3 Chain: A
Molecule details ›
Chain: A
Length: 72 amino acids
Theoretical weight: 8.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95983 (Residues: 1-70; Coverage: 24%)
Gene name: MBD3
Sequence domains: Methyl-CpG binding domain
Structure domains: Methyl-cpg-binding Protein 2; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Methyl-CpG-binding domain proteins: readers of the epigenome.
Du et al. (2015)
8 more

4 mentions without citation

Refinement of the subunit interaction network within the nucleosome remodelling and deacetylase (NuRD) complex.
Torrado et al. (2017)
3 more