› 2mbj

Solution NMR

Structure of an antiparallel (2+2) G-quadruplex formed by human telomeric repeats in Na+ solution (with G22-to-BrG substitution)

Released:
DOI: 10.2210/pdb2mbj/pdb
PDB entry 2mbj coloured by chain, ensemble of 10 models, front view.
PDB entry 2mbj coloured by chain, ensemble of 10 models, side view.
PDB entry 2mbj coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity.
Lim KW, Ng VC, Martín-Pintado N, Heddi B, Phan AT
Nucleic Acids Res 41 10556-62 (2013)
PMID: 23999095

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115606 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA_(27-MER) Chain: A
Molecule details ›
Chain: A
Length: 27 nucleotides
Theoretical weight: 8.59 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand BGM 1 x BGM

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 38%
Refinement method: DGSA-distance geometry simulated annealing, Distance-restrained molecular dynamics
Expression system: Not provided

Quick links

Citations

8 review citations

G4-associated human diseases.
Maizels N. (2015)
7 more

9 mentions without citation

Developing Novel G-Quadruplex Ligands: from Interaction with Nucleic Acids to Interfering with Nucleic Acid⁻Protein Interaction.
Sun et al. (2019)
8 more