› 2md5

Solution NMR

Structure of uninhibited ETV6 ETS domain

Released:
DOI: 10.2210/pdb2md5/pdb
PDB entry 2md5 coloured by chain, ensemble of 10 models, front view.
PDB entry 2md5 coloured by chain, ensemble of 10 models, side view.
PDB entry 2md5 coloured by chain, ensemble of 10 models, top view.
Source organism: Mus musculus
Primary publication:
Steric mechanism of auto-inhibitory regulation of specific and non-specific DNA binding by the ETS transcriptional repressor ETV6.
De S, Chan AC, Coyne HJ, Bhachech N, Hermsdorf U, Okon M, Murphy ME, Graves BJ, McIntosh LP
J Mol Biol 426 1390-406 (2014)
PMID: 24333486

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161294 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription factor ETV6 Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 12.45 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P97360 (Residues: 329-426; Coverage: 20%)
Gene names: Etv6, Tel, Tel1
Sequence domains: Ets-domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 78%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

3 review citations

ETV6 and ETV7: Siblings in hematopoiesis and its disruption in disease.
Rasighaemi et al. (2017)
2 more

1 mention without citation

Steric mechanism of auto-inhibitory regulation of specific and non-specific DNA binding by the ETS transcriptional repressor ETV6.
De et al. (2014)