› 2md7

Solution NMR

NMR structure of human Sp140 PHD finger trans conformer

Released:
DOI: 10.2210/pdb2md7/pdb
PDB entry 2md7 coloured by chain, ensemble of 20 models, front view.
PDB entry 2md7 coloured by chain, ensemble of 20 models, side view.
PDB entry 2md7 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1.
Zucchelli C, Tamburri S, Quilici G, Palagano E, Berardi A, Saare M, Peterson P, Bachi A, Musco G
FEBS J 281 216-31 (2014)
PMID: 24267382

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171647 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear body protein SP140 Chain: B
Molecule details ›
Chain: B
Length: 56 amino acids
Theoretical weight: 6.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13342 (Residues: 687-738; Coverage: 6%)
Gene names: LYSP100, SP140
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 79%
Refinement method: simulated annealing, distance geometry
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

The Expanding Landscape of Alternative Splicing Variation in Human Populations.
Park et al. (2018)
1 more