› 2mgx

Solution NMR

NMR structure of SRA1p C-terminal domain

Released:
DOI: 10.2210/pdb2mgx/pdb
PDB entry 2mgx coloured by chain, ensemble of 15 models, front view.
PDB entry 2mgx coloured by chain, ensemble of 15 models, side view.
PDB entry 2mgx coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
The C-terminal domain of SRA1p has a fold more similar to PRP18 than to an RRM and does not directly bind to the SRA1 RNA STR7 region.
Bilinovich SM, Davis CM, Morris DL, Ray LA, Prokop JW, Buchan GJ, Leeper TC
J Mol Biol 426 1753-65 (2014)
PMID: 24486611

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190799 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Steroid receptor RNA activator 1 Chain: A
Molecule details ›
Chain: A
Length: 131 amino acids
Theoretical weight: 14.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HD15 (Residues: 95-224; Coverage: 58%)
Gene names: PP7684, SRA1
Sequence domains: Steroid receptor RNA activator (SRA1)
Structure domains: Functional domain of the splicing factor Prp18

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

3 citation in other articles

Intrinsically disordered proteins in the nucleus of human cells.
Frege et al. (2015)
2 more

1 mention without citation

Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network.
Hutchings et al. (2021)