› 2mha

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I H-2KB MOLECULE CONTAINING A SINGLE VIRAL PEPTIDE: IMPLICATIONS FOR PEPTIDE BINDING AND T-CELL RECEPTOR RECOGNITION

Released:
DOI: 10.2210/pdb2mha/pdb
PDB entry 2mha coloured by chain, front view.
PDB entry 2mha coloured by chain, side view.
PDB entry 2mha coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.
Zhang W, Young AC, Imarai M, Nathenson SG, Sacchettini JC
Proc Natl Acad Sci U S A 89 8403-7 (1992)
PMID: 1325657

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135046 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
H-2 class I histocompatibility antigen, K-B alpha chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 270 amino acids
Theoretical weight: 31.09 KDa
Source organism: Mus musculus
Expression system: unidentified
UniProt:
  • Canonical: P01901 (Residues: 22-291; Coverage: 78%)
Gene names: H2-K, H2-K1
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, D
Molecule details ›
Chains: B, D
Length: 99 amino acids
Theoretical weight: 11.7 KDa
Source organism: Mus musculus
Expression system: unidentified
UniProt:
  • Canonical: P01887 (Residues: 21-119; Coverage: 100%)
Gene name: B2m
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Nucleoprotein Chains: E, F
Molecule details ›
Chains: E, F
Length: 8 amino acids
Theoretical weight: 956 Da
Source organism: Vesicular stomatitis virus
Expression system: Not provided
UniProt:
  • Canonical: P11212 (Residues: 52-59; Coverage: 2%)
Gene name: N

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 90.9Å b: 92.2Å c: 67.5Å
α: 90° β: 111.24° γ: 90°
R-values:
R R work R free
0.184 0.184 not available
Expression systems:
  • unidentified
  • Not provided

Quick links

Citations

28 review citations

MHC ligands and peptide motifs: first listing.
Rammensee et al. (1995)
27 more

3 mentions without citation

Decanoic Acid Stimulates Autophagy in D. discoideum.
Warren et al. (2021)
2 more