› 2mhs

Solution NMR

NMR Structure of human Mcl-1

Released:
DOI: 10.2210/pdb2mhs/pdb
PDB entry 2mhs coloured by chain, ensemble of 20 models, front view.
PDB entry 2mhs coloured by chain, ensemble of 20 models, side view.
PDB entry 2mhs coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
High-quality NMR structure of human anti-apoptotic protein domain Mcl-1(171-327) for cancer drug design.
Liu G, Poppe L, Aoki K, Yamane H, Lewis J, Szyperski T
PLoS One 9 e96521 (2014)
PMID: 24789074

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170534 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Induced myeloid leukemia cell differentiation protein Mcl-1 Chain: A
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 18.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07820 (Residues: 171-327; Coverage: 45%)
Gene names: BCL2L3, MCL1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: distance geometry, molecular dynamics, simulated annealing, torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Understanding MCL1: from cellular function and regulation to pharmacological inhibition.
Sancho et al. (2022)
8 other articles

10 mentions without citation

Physiological and Pharmacological Control of BAK, BAX, and Beyond.
Luna-Vargas et al. (2016)
9 more