› 2miw

Solution NMR

Nuclear magnetic resonance studies of N2-guanine adducts derived from the tumorigen dibenzo[a,l]pyrene in DNA: Impact of adduct stereochemistry, size, and local DNA structure on solution conformations

Released:
DOI: 10.2210/pdb2miw/pdb
PDB entry 2miw coloured by chain, front view.
PDB entry 2miw coloured by chain, side view.
PDB entry 2miw coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Nuclear magnetic resonance studies of an N2-guanine adduct derived from the tumorigen dibenzo[a,l]pyrene in DNA: impact of adduct stereochemistry, size, and local DNA sequence on solution conformations.
Rodríguez FA, Liu Z, Lin CH, Ding S, Cai Y, Kolbanovskiy A, Kolbanovskiy M, Amin S, Broyde S, Geacintov NE
Biochemistry 53 1827-41 (2014)
PMID: 24617538

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115621 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA_(5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 11 nucleotides
Theoretical weight: 3.25 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA_(5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.45 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand 2QL 1 x 2QL
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 29%
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

2 review citations

Repair-Resistant DNA Lesions.
Geacintov et al. (2017)
1 more

2 mentions without citation

Cytotoxic Effects of Dimorfolido-N-Trichloroacetylphosphorylamide and Dimorfolido-N-Benzoylphosphorylamide in Combination with C60 Fullerene on Leukemic Cells and Docking Study of Their Interaction with DNA.
Prylutska et al. (2017)
1 more