› 2miz

Solution NMR

Structure of the m04/gp34 mouse Cytomegalovirus Immunoevasin core domain

Released:
DOI: 10.2210/pdb2miz/pdb
PDB entry 2miz coloured by chain, ensemble of 10 models, front view.
PDB entry 2miz coloured by chain, ensemble of 10 models, side view.
PDB entry 2miz coloured by chain, ensemble of 10 models, top view.
Source organism: Murine cytomegalovirus (strain K181)
Primary publication:
The structure of mouse cytomegalovirus m04 protein obtained from sparse NMR data reveals a conserved fold of the m02-m06 viral immune modulator family.
Sgourakis NG, Natarajan K, Ying J, Vogeli B, Boyd LF, Margulies DH, Bax A
Structure 22 1263-1273 (2014)
PMID: 25126960

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106921 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
M04 immunoevasin Chain: A
Molecule details ›
Chain: A
Length: 200 amino acids
Theoretical weight: 22.8 KDa
Source organism: Murine cytomegalovirus (strain K181)
Expression system: Escherichia coli
UniProt:
  • Canonical: A2Q6L0 (Residues: 23-219; Coverage: 74%)
Gene name: m04
Sequence domains: Immune evasion protein
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 38%
Refinement method: RASREC
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Modulation of innate and adaptive immunity by cytomegaloviruses.
Berry et al. (2020)
2 more

3 mentions without citation

Chemical shift-based methods in NMR structure determination.
Nerli et al. (2018)
2 more