› 2mj8

Solution NMR

Solution structure of CDYL2 chromodomain

Released:
DOI: 10.2210/pdb2mj8/pdb
PDB entry 2mj8 coloured by chain, ensemble of 20 models, front view.
PDB entry 2mj8 coloured by chain, ensemble of 20 models, side view.
PDB entry 2mj8 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin S, Wang Y, Min J
Cell Chem Biol 27 827-838.e7 (2020)
PMID: 32470319

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185442 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chromodomain Y-like protein 2 Chain: A
Molecule details ›
Chain: A
Length: 64 amino acids
Theoretical weight: 7.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N8U2 (Residues: 2-64; Coverage: 13%)
Gene name: CDYL2
Sequence domains: Chromo (CHRromatin Organisation MOdifier) domain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 75%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Chemical tools targeting readers of lysine methylation.
Ortiz et al. (2023)
2 other articles