› 2mj9

Solution NMR

Designed Exendin-4 analogues

Released:
DOI: 10.2210/pdb2mj9/pdb
PDB entry 2mj9 coloured by chain, ensemble of 10 models, front view.
PDB entry 2mj9 coloured by chain, ensemble of 10 models, side view.
PDB entry 2mj9 coloured by chain, ensemble of 10 models, top view.
Source organism: Heloderma suspectum
Primary publication:
Rational design of α-helix-stabilized exendin-4 analogues.
Rovó P, Farkas V, Stráner P, Szabó M, Jermendy A, Hegyi O, Tóth GK, Perczel A
Biochemistry 53 3540-52 (2014)
PMID: 24828921

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150707 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Exendin-4 Chain: A
Molecule details ›
Chain: A
Length: 39 amino acids
Theoretical weight: 4.31 KDa
Source organism: Heloderma suspectum
Expression system: Escherichia coli
UniProt:
  • Canonical: P26349 (Residues: 48-86; Coverage: 61%)
Sequence domains: Peptide hormone

Ligands and Environments

No bound ligands
1 modified residue:
Ligand DAL 1 x DAL

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 52%
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

1 review citation

Exendin-4 from Heloderma suspectum venom: From discovery to its latest application as type II diabetes combatant.
Yap et al. (2019)
10 other articles