› 2mk3

Solution NMR

Solution NMR structure of gp41 ectodomain monomer on a DPC micelle

Released:
DOI: 10.2210/pdb2mk3/pdb
PDB entry 2mk3 coloured by chain, ensemble of 20 models, front view.
PDB entry 2mk3 coloured by chain, ensemble of 20 models, side view.
PDB entry 2mk3 coloured by chain, ensemble of 20 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Dissociation of the trimeric gp41 ectodomain at the lipid-water interface suggests an active role in HIV-1 Env-mediated membrane fusion.
Roche J, Louis JM, Grishaev A, Ying J, Bax A
Proc Natl Acad Sci U S A 111 3425-30 (2014)
PMID: 24550514

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112127 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane glycoprotein Chain: A
Molecule details ›
Chain: A
Length: 72 amino acids
Theoretical weight: 8.29 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: D0VWW0 (Residues: 5-38, 50-77; Coverage: 27%)
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 44%
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

2 review citations

How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.
Pancera et al. (2017)
1 more

2 mentions without citation

Dissociation of the trimeric gp41 ectodomain at the lipid-water interface suggests an active role in HIV-1 Env-mediated membrane fusion.
Roche et al. (2014)
1 more