› 2mke

Solution NMR

Solution structure of CPEB1 ZZ domain in the free state

Released:
DOI: 10.2210/pdb2mke/pdb
PDB entry 2mke coloured by chain, ensemble of 26 models, front view.
PDB entry 2mke coloured by chain, ensemble of 26 models, side view.
PDB entry 2mke coloured by chain, ensemble of 26 models, top view.
Source organism: Homo sapiens
Primary publication:
A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins.
Afroz T, Skrisovska L, Belloc E, Guillén-Boixet J, Méndez R, Allain FH
Genes Dev 28 1498-514 (2014)
PMID: 24990967

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189855 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytoplasmic polyadenylation element-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 7.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BZB8 (Residues: 506-566; Coverage: 11%)
Gene names: CPEB, CPEB1
Sequence domains: Cytoplasmic polyadenylation element-binding protein ZZ domain
Structure domains: Cytoplasmic polyadenylation element-binding protein, ZZ domain

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 78%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Cellular and System Biology of Memory: Timing, Molecules, and Beyond.
Korte et al. (2016)
10 more

2 mentions without citation

A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins.
Afroz et al. (2014)
1 more