› 2mlo

Solution NMR

Human CCR2 Membrane-Proximal C-Terminal Region (PRO-C) in a Membrane bound form

Released:
DOI: 10.2210/pdb2mlo/pdb
PDB entry 2mlo coloured by chain, ensemble of 20 models, front view.
PDB entry 2mlo coloured by chain, ensemble of 20 models, side view.
PDB entry 2mlo coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT.
Esaki K, Yoshinaga S, Tsuji T, Toda E, Terashima Y, Saitoh T, Kohda D, Kohno T, Osawa M, Ueda T, Shimada I, Matsushima K, Terasawa H
FEBS J 281 5552-66 (2014)
PMID: 25283965

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154415 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C chemokine receptor type 2 Chain: A
Molecule details ›
Chain: A
Length: 16 amino acids
Theoretical weight: 2.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41597 (Residues: 310-318; Coverage: 2%)
Gene names: CCR2, CMKBR2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 79%
Expression system: Escherichia coli

Quick links

Citations

6 citation in other articles

Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties.
Terashima et al. (2020)
5 more