› 2mpc

Solution NMR

Solution structure of the pyrin domain of human Pyrin

Released:
DOI: 10.2210/pdb2mpc/pdb
PDB entry 2mpc coloured by chain, ensemble of 10 models, front view.
PDB entry 2mpc coloured by chain, ensemble of 10 models, side view.
PDB entry 2mpc coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly.
Vajjhala PR, Kaiser S, Smith SJ, Ong QR, Soh SL, Stacey KJ, Hill JM
J Biol Chem 289 23504-19 (2014)
PMID: 25006247

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127532 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyrin Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15553 (Residues: 1-92; Coverage: 12%)
Gene names: MEF, MEFV, TRIM20
Sequence domains: PAAD/DAPIN/Pyrin domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 44%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Inflammasome activation and regulation: toward a better understanding of complex mechanisms.
Zheng et al. (2020)
9 more

3 mentions without citation

The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines.
Hauenstein et al. (2015)
2 more