› 2ms6

Solution NMR

Human Telomeric G-quadruplex DNA sequence (TTAGGGT)4 complexed with Flavonoid Quercetin

Released:
DOI: 10.2210/pdb2ms6/pdb
PDB entry 2ms6 coloured by chain, front view.
PDB entry 2ms6 coloured by chain, side view.
PDB entry 2ms6 coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Structural Insight into the interaction of Flavonoids with Human Telomeric Sequence.
Tawani A, Kumar A
Sci Rep 5 17574 (2015)
PMID: 26627543

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115641 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA_(5'-D(*TP*TP*AP*GP*GP*GP*T)-3') Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 7 nucleotides
Theoretical weight: 2.17 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand QUE 2 x QUE
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 10%
Refinement method: molecular dynamics
Expression system: Not provided

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Citations

9 review citations

Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake.
Rysz et al. (2021)
8 more

3 mentions without citation

Insights into the Small Molecule Targeting of Biologically Relevant G-Quadruplexes: An Overview of NMR and Crystal Structures.
Criscuolo et al. (2022)
2 more