› 2msy

Solution NMR

Solution structure of Hox homeodomain

Released:
DOI: 10.2210/pdb2msy/pdb
PDB entry 2msy coloured by chain, ensemble of 20 models, front view.
PDB entry 2msy coloured by chain, ensemble of 20 models, side view.
PDB entry 2msy coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into the interaction between the Hox and HMGB1 and understanding of the HMGB1-enhancing effect of Hox-DNA binding.
Kim HH, Park SJ, Han JH, Pathak C, Cheong HK, Lee BJ
Biochim Biophys Acta 1854 449-59 (2015)
PMID: 25707357

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151975 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homeobox protein Hox-C9 Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 8.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31274 (Residues: 184-251; Coverage: 26%)
Gene names: HOX3B, HOXC9
Sequence domains: Homeodomain
Structure domains: Homeodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 78%
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

3 citation in other articles

Mechanisms of Specificity for Hox Factor Activity.
Zandvakili et al. (2016)
2 more