Function and Biology Details
Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
RNA-directed RNA polymerase (preferred)
PDBe Complex ID:
PDB-CPX-131655 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Viroporin p7
Molecule details ›
Chain: A
Length: 63 amino acids
Theoretical weight: 6.69 KDa
Source organism: Hepatitis C virus isolate HC-J4
Expression system: Escherichia coli BL21(DE3)
UniProt:
Length: 63 amino acids
Theoretical weight: 6.69 KDa
Source organism: Hepatitis C virus isolate HC-J4
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
O92972 (Residues: 747-809; Coverage: 2%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Chemical shift assignment:
20%
Refinement method:
simulated annealing
Expression system: Escherichia coli BL21(DE3)
