› 2mv1

Solution NMR

Solution NMR structure of Human Relaxin-2

Released:
DOI: 10.2210/pdb2mv1/pdb
PDB entry 2mv1 coloured by chain, ensemble of 20 models, front view.
PDB entry 2mv1 coloured by chain, ensemble of 20 models, side view.
PDB entry 2mv1 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure, aggregation behavior, and flexibility of human relaxin-2.
Haugaard-Kedström LM, Hossain MA, Daly NL, Bathgate RA, Rinderknecht E, Wade JD, Craik DJ, Rosengren KJ
ACS Chem Biol 10 891-900 (2015)
PMID: 25547165

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137401 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Relaxin B chain Chain: B
Molecule details ›
Chain: B
Length: 30 amino acids
Theoretical weight: 3.31 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04090 (Residues: 25-53; Coverage: 18%)
Gene name: RLN2
Relaxin A chain Chain: A
Molecule details ›
Chain: A
Length: 25 amino acids
Theoretical weight: 2.66 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04090 (Residues: 163-185; Coverage: 14%)
Gene name: RLN2

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 31%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

1 review citation

The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors.
Vu et al. (2021)
10 other articles

3 mentions without citation

Relaxin family peptides: structure-activity relationship studies.
Patil et al. (2017)
2 more