› 2mw3

Solution NMR

Solution NMR structure of the lasso peptide streptomonomicin

Released:
DOI: 10.2210/pdb2mw3/pdb
PDB entry 2mw3 coloured by chain, ensemble of 15 models, front view.
PDB entry 2mw3 coloured by chain, ensemble of 15 models, side view.
PDB entry 2mw3 coloured by chain, ensemble of 15 models, top view.
Source organism: Streptomonospora alba
Primary publication:
Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete.
Metelev M, Tietz JI, Melby JO, Blair PM, Zhu L, Livnat I, Severinov K, Mitchell DA
Chem Biol 22 241-50 (2015)
PMID: 25601074

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-101044 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Streptomonomicin peptide protein Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.25 KDa
Source organism: Streptomonospora alba
UniProt:
  • Canonical: A0A0C2JEQ8 (Residues: 21-41; Coverage: 51%)
Gene name: LP52_05076

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 62%
Refinement method: simulated annealing

Quick links

Citations

17 review citations

New developments in RiPP discovery, enzymology and engineering.
Montalbán-López et al. (2021)
16 more

3 mentions without citation

Recent Advances and Perspectives on Expanding the Chemical Diversity of Lasso Peptides.
Wang et al. (2021)
2 more