› 2mw7

Solution NMR

Solution NMR structure of a novel cysteine framework containing Conus peptide Mo3964

Released:
DOI: 10.2210/pdb2mw7/pdb
PDB entry 2mw7 coloured by chain, ensemble of 20 models, front view.
PDB entry 2mw7 coloured by chain, ensemble of 20 models, side view.
PDB entry 2mw7 coloured by chain, ensemble of 20 models, top view.
Source organism: Conus monile
Primary publication:
A Disulfide Stabilized β-Sandwich Defines the Structure of a New Cysteine Framework M-Superfamily Conotoxin.
Kancherla AK, Meesala S, Jorwal P, Palanisamy R, Sikdar SK, Sarma SP
ACS Chem Biol 10 1847-60 (2015)
PMID: 25961405

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102615 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Delta/kappa-conotoxin Mo3964 Chain: A
Molecule details ›
Chain: A
Length: 37 amino acids
Theoretical weight: 3.97 KDa
Source organism: Conus monile
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A0R4I952 (Residues: 1-37; Coverage: 100%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 94%
Refinement method: torsion angle dynamics, molecular dynamics
Expression system: Escherichia coli BL21(DE3)

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Citations

2 citation in other articles

A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus).
Huang et al. (2017)
1 more

2 mentions without citation

A Disulfide Stabilized β-Sandwich Defines the Structure of a New Cysteine Framework M-Superfamily Conotoxin.
Kancherla et al. (2015)
1 more