› 2n2o

Solution NMR

Structure of murine tumour necrosis factor alpha CDE RNA

Released:
DOI: 10.2210/pdb2n2o/pdb
PDB entry 2n2o coloured by chain, ensemble of 10 models, front view.
PDB entry 2n2o coloured by chain, ensemble of 10 models, side view.
PDB entry 2n2o coloured by chain, ensemble of 10 models, top view.
Source organism: synthetic construct
Primary publication:
A Distinct, Sequence-Induced Conformation Is Required for Recognition of the Constitutive Decay Element RNA by Roquin.
Codutti L, Leppek K, Zálešák J, Windeisen V, Masiewicz P, Stoecklin G, Carlomagno T
Structure 23 1437-1447 (2015)
PMID: 26165594

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196516 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (5'-R(P*GP*CP*AP*UP*GP*UP*UP*UP*UP*CP*UP*GP*UP*GP*AP*AP*AP*AP*CP*GP*GP*UP*U)-3') Chain: A
Molecule details ›
Chain: A
Length: 23 nucleotides
Theoretical weight: 7.34 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

5 review citations

Post-transcriptional regulation of immune responses by RNA binding proteins.
Mino et al. (2018)
4 more

1 mention without citation

Exogenous acetate ion reaches the type II copper centre in CueO through the water-excretion channel and potentially affects the enzymatic activity.
Komori et al. (2016)