› 2n4m

Solution NMR

Base-displaced intercalated structure of the N-(2'deoxyguanosin-8-yl)-3-aminobenzanthrone DNA adduct

Released:
DOI: 10.2210/pdb2n4m/pdb
PDB entry 2n4m coloured by chain, ensemble of 10 models, front view.
PDB entry 2n4m coloured by chain, ensemble of 10 models, side view.
PDB entry 2n4m coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Base-Displaced Intercalated Structure of the N-(2'-Deoxyguanosin-8-yl)-3-aminobenzanthrone DNA Adduct.
Politica DA, Malik CK, Basu AK, Stone MP
Chem Res Toxicol 28 2253-66 (2015)
PMID: 26641105

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115649 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(*GP*TP*GP*CP*(4E9)P*TP*GP*TP*TP*TP*GP*T)-3') Chain: A
Molecule details ›
Chain: A
Length: 12 nucleotides
Theoretical weight: 3.96 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(*AP*CP*AP*AP*AP*CP*AP*CP*GP*CP*AP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 12 nucleotides
Theoretical weight: 3.61 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 34%
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

1 review citation

Repair-Resistant DNA Lesions.
Geacintov et al. (2017)
4 other articles

1 mention without citation

Base-Displaced Intercalated Structure of the N-(2'-Deoxyguanosin-8-yl)-3-aminobenzanthrone DNA Adduct.
Politica et al. (2015)