› 2n4p

Solution NMR

Solution structure of the n-terminal domain of tdp-43

Released:
DOI: 10.2210/pdb2n4p/pdb
PDB entry 2n4p coloured by chain, ensemble of 20 models, front view.
PDB entry 2n4p coloured by chain, ensemble of 20 models, side view.
PDB entry 2n4p coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The TDP-43 N-terminal domain structure at high resolution.
Mompeán M, Romano V, Pantoja-Uceda D, Stuani C, Baralle FE, Buratti E, Laurents DV
FEBS J 283 1242-60 (2016)
PMID: 26756435

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171557 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TAR DNA-binding protein 43 Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 9.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13148 (Residues: 1-77; Coverage: 19%)
Gene names: TARDBP, TDP43
Sequence domains: TAR DNA-binding protein 43, N-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: ENERGY MINIMIZATION
Expression system: Escherichia coli

Quick links

Citations

17 review citations

TDP-43 proteinopathies: a new wave of neurodegenerative diseases.
de Boer et al. (2020)
16 more

16 mentions without citation

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis.
Prasad et al. (2019)
15 more