› 2n4y

Solution NMR

Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome

Released:
DOI: 10.2210/pdb2n4y/pdb
PDB entry 2n4y coloured by chain, ensemble of 10 models, front view.
PDB entry 2n4y coloured by chain, ensemble of 10 models, side view.
PDB entry 2n4y coloured by chain, ensemble of 10 models, top view.
Source organism: synthetic construct
Primary publication:
Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome.
De Nicola B, Lech CJ, Heddi B, Regmi S, Frasson I, Perrone R, Richter SN, Phan AT
OpenAccess logo Nucleic Acids Res 44 6442-51 (2016)
PMID: 27298260

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115650 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA_(5'-D(*CP*TP*GP*GP*GP*CP*GP*GP*GP*AP*CP*TP*GP*GP*GP*GP*AP*GP*TP*GP*GP*T)-3') Chain: A
Molecule details ›
Chain: A
Length: 22 nucleotides
Theoretical weight: 6.95 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 44%
Refinement method: distance geometry, DGSA-distance geometry simulated annealing, simulated annealing, molecular dynamics
Expression system: Not provided

Quick links

Citations

12 review citations

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy.
Ruggiero et al. (2018)
11 more

9 mentions without citation

Structural motifs and intramolecular interactions in non-canonical G-quadruplexes.
Jana et al. (2021)
8 more