› 2n7l

Solution NMR

NMR structure of the N-domain of troponin C bound to the switch region of troponin I and the covalent levosimendan analog i9

Released:
DOI: 10.2210/pdb2n7l/pdb
PDB entry 2n7l coloured by chain, ensemble of 20 models, front view.
PDB entry 2n7l coloured by chain, ensemble of 20 models, side view.
PDB entry 2n7l coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Pineda Sanabria SE, Sykes BD, Robertson IM

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148572 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles; Troponin I, cardiac muscle Chain: C
Molecule details ›
Chain: C
Length: 141 amino acids
Theoretical weight: 16.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 1-89; Coverage: 55%)
  • Canonical: P19429 (Residues: 145-174; Coverage: 14%)
Gene names: TNNC, TNNC1, TNNI3
Sequence domains: EF-hand domain pair

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
1 modified residue:
Ligand 4J4 1 x 4J4

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 69%
Refinement method: simulated annealing
Expression system: Escherichia coli

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