› 2n7y

Solution NMR

NMR structure of metal-binding domain 1 of ATP7B

Released:
DOI: 10.2210/pdb2n7y/pdb
PDB entry 2n7y coloured by chain, ensemble of 20 models, front view.
PDB entry 2n7y coloured by chain, ensemble of 20 models, side view.
PDB entry 2n7y coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The Structure of Metal Binding Domain 1 of the Copper Transporter ATP7B Reveals Mechanism of a Singular Wilson Disease Mutation.
Yu CH, Lee W, Nokhrin S, Dmitriev OY
Sci Rep 8 581 (2018)
PMID: 29330485

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152990 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Copper-transporting ATPase 2 Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 8.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35670 (Residues: 56-127; Coverage: 5%)
Gene names: ATP7B, PWD, WC1, WND
Sequence domains: Heavy-metal-associated domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Cu Homeostasis in Bacteria: The Ins and Outs.
Andrei et al. (2020)
3 other articles

3 mentions without citation

The six metal binding domains in human copper transporter, ATP7B: molecular biophysics and disease-causing mutations.
Ariöz et al. (2017)
2 more