› 2n8h

Solution NMR

Structural basis for the inhibition of voltage-gated sodium channels with conotoxin-muOxi-GVIIJ

Released:
DOI: 10.2210/pdb2n8h/pdb
PDB entry 2n8h coloured by chain, ensemble of 20 models, front view.
PDB entry 2n8h coloured by chain, ensemble of 20 models, side view.
PDB entry 2n8h coloured by chain, ensemble of 20 models, top view.
Source organism: Conus geographus
Primary publication:
Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.
Green BR, Gajewiak J, Chhabra S, Skalicky JJ, Zhang MM, Rivier JE, Bulaj G, Olivera BM, Yoshikami D, Norton RS
J Biol Chem 291 7205-20 (2016)
PMID: 26817840

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197871 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-conotoxin GVIIJ Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 3.73 KDa
Source organism: Conus geographus
Expression system: Not provided
UniProt:
  • Canonical: X5IWS1 (Residues: 48-82; Coverage: 58%)
Sequence domains: Conotoxin

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 1 x HYP

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 71%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

1 review citation

µ-Conotoxins Modulating Sodium Currents in Pain Perception and Transmission: A Therapeutic Potential.
Tosti et al. (2017)
1 other article

2 mentions without citation

Exploring the Pivotal Components Influencing the Side Effects Induced by an Analgesic-Antitumor Peptide from Scorpion Venom on Human Voltage-Gated Sodium Channels 1.4 and 1.5 through Computational Simulation.
Zhao et al. (2022)
1 more