› 2n97

Solution NMR

DD homodimer

Released:
DOI: 10.2210/pdb2n97/pdb
PDB entry 2n97 coloured by chain, ensemble of 10 models, front view.
PDB entry 2n97 coloured by chain, ensemble of 10 models, side view.
PDB entry 2n97 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of death domain signaling in the p75 neurotrophin receptor.
Lin Z, Tann JY, Goh ET, Kelly C, Lim KB, Gao JF, Ibanez CF
Elife 4 e11692 (2015)
PMID: 26646181

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139929 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor receptor superfamily member 16 Chains: A, B
Molecule details ›
Chains: A, B
Length: 98 amino acids
Theoretical weight: 10.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08138 (Residues: 330-427; Coverage: 25%)
Gene names: NGFR, TNFRSF16
Sequence domains: Death domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 39%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Recent advances in understanding neurotrophin signaling.
Bothwell M. (2016)
11 more

5 mentions without citation

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex.
Kelly et al. (2008)
4 more