› 2nnr

X-ray diffraction
1.7Å resolution

Crystal structure of chagasin, cysteine protease inhibitor from Trypanosoma cruzi

Released:
DOI: 10.2210/pdb2nnr/pdb
PDB entry 2nnr coloured by chain, front view.
PDB entry 2nnr coloured by chain, side view.
PDB entry 2nnr coloured by chain, top view.
Source organism: Trypanosoma cruzi
Primary publication:
Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease.
Ljunggren A, Redzynia I, Alvarez-Fernandez M, Abrahamson M, Mort JS, Krupa JC, Jaskolski M, Bujacz G
J Mol Biol 371 137-53 (2007)
PMID: 17561110

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188320 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chagasin Chains: A, B
Molecule details ›
Chains: A, B
Length: 110 amino acids
Theoretical weight: 12.05 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q966X9 (Residues: 1-110; Coverage: 100%)
Gene name: cha
Sequence domains: Chagasin family peptidase inhibitor I42
Structure domains: Immunoglobulin-like

Ligands and Environments

3 bound ligands:
Ligand SO4 1 x SO4
Ligand GOL 7 x GOL
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11, EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: P3112
Unit cell:
a: 49.546Å b: 49.546Å c: 187.576Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.186 0.216
Expression system: Escherichia coli BL21

Quick links

Citations

7 review citations

Interactions between intestinal compounds of triatomines and Trypanosoma cruzi.
Garcia et al. (2010)
6 more

4 mentions without citation

The role of cystatins in tick physiology and blood feeding.
Schwarz et al. (2012)
3 more