› 2nnt

Solid-state NMR

General structural motifs of amyloid protofilaments

Released:
DOI: 10.2210/pdb2nnt/pdb
PDB entry 2nnt coloured by chain, ensemble of 10 models, front view.
PDB entry 2nnt coloured by chain, ensemble of 10 models, side view.
PDB entry 2nnt coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
General structural motifs of amyloid protofilaments.
Ferguson N, Becker J, Tidow H, Tremmel S, Sharpe TD, Krause G, Flinders J, Petrovich M, Berriman J, Oschkinat H, Fersht AR
Proc Natl Acad Sci U S A 103 16248-53 (2006)
PMID: 17060612

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127128 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription elongation regulator 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 40 amino acids
Theoretical weight: 4.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14776 (Residues: 428-464; Coverage: 3%)
Gene names: CA150, TAF2S, TCERG1
Sequence domains: WW domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

19 review citations

Functional amyloid--from bacteria to humans.
Fowler et al. (2007)
18 more

6 mentions without citation

Structural motifs of biomolecules.
Banavar et al. (2007)
5 more