› 2not

X-ray diffraction
3Å resolution

NOTECHIS II-5, NEUROTOXIC PHOSPHOLIPASE A2 FROM NOTECHIS SCUTATUS SCUTATUS

Released:
DOI: 10.2210/pdb2not/pdb
PDB entry 2not coloured by chain, front view.
PDB entry 2not coloured by chain, side view.
PDB entry 2not coloured by chain, top view.
Source organism: Notechis scutatus scutatus
Primary publication:
The three-dimensional structures of two toxins from snake venom throw light on the anticoagulant and neurotoxic sites of phospholipase A2.
Carredano E, Westerlund B, Persson B, Saarinen M, Ramaswamy S, Eaker D, Eklund H
Toxicon 36 75-92 (1998)
PMID: 9604284

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132756 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 notechis II-5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 119 amino acids
Theoretical weight: 13.7 KDa
Source organism: Notechis scutatus scutatus
UniProt:
  • Canonical: P00609 (Residues: 1-119; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P212121
Unit cell:
a: 39.5Å b: 43.5Å c: 145Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.219 0.255

Quick links

Citations

8 review citations

Neurotoxins affecting neuroexocytosis.
Schiavo et al. (2000)
7 more