› 2nq5

X-ray diffraction
1.9Å resolution

Crystal structure of methyltransferase from Streptococcus mutans

Released:
DOI: 10.2210/pdb2nq5/pdb
PDB entry 2nq5 coloured by chain, front view.
PDB entry 2nq5 coloured by chain, side view.
PDB entry 2nq5 coloured by chain, top view.
Source organism: Streptococcus mutans
Entry authors: Fedorov AA, Fedorov EV, Sauder JM, Burley SK, Almo SC, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed: 
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184020 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Chain: A
Molecule details ›
Chain: A
Length: 755 amino acids
Theoretical weight: 85.46 KDa
Source organism: Streptococcus mutans
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8CWX6 (Residues: 2-745; Coverage: 100%)
Gene names: SMU_873, metE
Sequence domains:
Structure domains: TIM Barrel

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 52.291Å b: 99.194Å c: 78.619Å
α: 90° β: 109.25° γ: 90°
R-values:
R R work R free
0.228 0.228 0.258
Expression system: Escherichia coli

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