› 2nyr

X-ray diffraction
2.06Å resolution

Crystal Structure of Human Sirtuin Homolog 5 in Complex with Suramin

Released:
DOI: 10.2210/pdb2nyr/pdb
PDB entry 2nyr coloured by chain, front view.
PDB entry 2nyr coloured by chain, side view.
PDB entry 2nyr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin.
Schuetz A, Min J, Antoshenko T, Wang CL, Allali-Hassani A, Dong A, Loppnau P, Vedadi M, Bochkarev A, Sternglanz R, Plotnikov AN
Structure 15 377-89 (2007)
PMID: 17355872

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192679 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacylase sirtuin-5, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 271 amino acids
Theoretical weight: 29.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NXA8 (Residues: 34-302; Coverage: 87%)
Gene names: SIR2L5, SIRT5
Sequence domains: Sir2 family
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand SVR 1 x SVR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 41.2Å b: 116.205Å c: 55.993Å
α: 90° β: 90.46° γ: 90°
R-values:
R R work R free
0.202 0.199 0.269
Expression system: Escherichia coli

Quick links

Citations

58 review citations

Erasers of histone acetylation: the histone deacetylase enzymes.
Seto et al. (2014)
57 more

13 mentions without citation

100 Years of Suramin.
Wiedemar et al. (2020)
12 more