› 2nz3

Solution NMR

NMR structure of DEF-AcAA, a mutant of anopheles defensin DEF-AAA

Released:
DOI: 10.2210/pdb2nz3/pdb
PDB entry 2nz3 coloured by chain, ensemble of 10 models, front view.
PDB entry 2nz3 coloured by chain, ensemble of 10 models, side view.
PDB entry 2nz3 coloured by chain, ensemble of 10 models, top view.
Source organism: Anopheles gambiae
Primary publication:
Rational design of peptides active against the gram positive bacteria Staphylococcus aureus.
Landon C, Barbault F, Legrain M, Guenneugues M, Vovelle F
Proteins 72 229-39 (2008)
PMID: 18214975

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Defensin Chain: A
Molecule details ›
Chain: A
Length: 40 amino acids
Theoretical weight: 4.35 KDa
Source organism: Anopheles gambiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q17027 (Residues: 63-102; Coverage: 52%)
Gene names: AGAP011294, Def1
Sequence domains: Arthropod defensin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Simulated annealing with torsion angle space (ARIA/CNS)
Expression system: Saccharomyces cerevisiae

Quick links

Citations

3 review citations

Computational tools for exploring sequence databases as a resource for antimicrobial peptides.
Porto et al. (2017)
2 more

4 mentions without citation

An Overview of Antimicrobial Compounds from African Edible Insects and Their Associated Microbiota.
Mudalungu et al. (2021)
3 more