› 2o03

X-ray diffraction
2.7Å resolution

Crystal structure of FurB from M. tuberculosis- a Zinc uptake regulator

Released:
DOI: 10.2210/pdb2o03/pdb
PDB entry 2o03 coloured by chain, front view.
PDB entry 2o03 coloured by chain, side view.
PDB entry 2o03 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Crystal structure and function of the zinc uptake regulator FurB from Mycobacterium tuberculosis.
Lucarelli D, Russo S, Garman E, Milano A, Meyer-Klaucke W, Pohl E
J Biol Chem 282 9914-9922 (2007)
PMID: 17213192

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161838 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc uptake regulation protein Chain: A
Molecule details ›
Chain: A
Length: 131 amino acids
Theoretical weight: 14.49 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P9WN85 (Residues: 2-130; Coverage: 99%)
Gene names: Rv2359, fur-2, furB, zur
Sequence domains: Ferric uptake regulator family
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P41212
Unit cell:
a: 51.6Å b: 51.6Å c: 133.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 0.239
Expression system: Escherichia coli BL21

Quick links

Citations

16 review citations

Coordination chemistry of bacterial metal transport and sensing.
Ma et al. (2009)
15 more

12 mentions without citation

Bacterial zinc uptake regulator proteins and their regulons.
Mikhaylina et al. (2018)
11 more