› 2o0i

X-ray diffraction
3.1Å resolution

crystal structure of the R185A mutant of the N-terminal domain of the Group B Streptococcus Alpha C protein

Released:
DOI: 10.2210/pdb2o0i/pdb
PDB entry 2o0i coloured by chain, front view.
PDB entry 2o0i coloured by chain, side view.
PDB entry 2o0i coloured by chain, top view.
Source organism: Streptococcus agalactiae serogroup Ia
Primary publication:
Identification of a glycosaminoglycan binding region of the alpha C protein that mediates entry of group B Streptococci into host cells.
Baron MJ, Filman DJ, Prophete GA, Hogle JM, Madoff LC
J Biol Chem 282 10526-36 (2007)
PMID: 17259175

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169682 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C protein alpha-antigen Chain: 1
Molecule details ›
Chain: 1
Length: 180 amino acids
Theoretical weight: 19.92 KDa
Source organism: Streptococcus agalactiae serogroup Ia
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q02192 (Residues: 57-225; Coverage: 17%)
Gene names: SAK_0517, bca
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-13
Spacegroup: P6122
Unit cell:
a: 55.7Å b: 55.7Å c: 277.94Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.245 0.268
Expression system: Escherichia coli BL21(DE3)

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Citations

8 review citations

Recent advances in understanding the molecular basis of group B Streptococcus virulence.
Maisey et al. (2008)
7 more