› 2o28

X-ray diffraction
1.8Å resolution

Crystal Structure of GNPNAT1

Released:
DOI: 10.2210/pdb2o28/pdb
PDB entry 2o28 coloured by chain, front view.
PDB entry 2o28 coloured by chain, side view.
PDB entry 2o28 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Min J, Wu H, Zeng H, Loppnau P, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188459 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucosamine 6-phosphate N-acetyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 184 amino acids
Theoretical weight: 20.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96EK6 (Residues: 1-184; Coverage: 100%)
Gene names: GNA1, GNPNAT1
Sequence domains: Acetyltransferase (GNAT) family
Structure domains: Aminopeptidase

Ligands and Environments


Cofactor: Ligand COA 2 x COA
1 bound ligand:
Ligand 16G 1 x 16G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 49.187Å b: 63.765Å c: 64.742Å
α: 90° β: 91.81° γ: 90°
R-values:
R R work R free
0.189 0.186 0.237
Expression system: Escherichia coli

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