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› 2o3t

X-ray diffraction
1.68Å resolution

Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38

Released:
DOI: 10.2210/pdb2o3t/pdb
Model geometry
Fit model/data
PDB entry 2o3t coloured by chain, front view.
PDB entry 2o3t coloured by chain, side view.
PDB entry 2o3t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38.
Liu Q, Kriksunov IA, Graeff R, Lee HC, Hao Q
J Biol Chem 282 5853-61 (2007)
PMID: 17182614

Function and Biology Details

Reactions catalysed: 
nicotinate + NADP(+) = nicotinate-adenine dinucleotide phosphate +nicotinamide.
NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+).
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151306 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 262 amino acids
Theoretical weight: 30.38 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P28907 (Residues: 45-300; Coverage: 85%)
Gene name: CD38
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CGR 1 x CGR
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: CHESS BEAMLINE A1
Spacegroup: P1
Unit cell:
a: 41.994Å b: 53.289Å c: 65.729Å
α: 105.9° β: 91.76° γ: 95.16°
R-values:
R R work R free
0.174 0.172 0.208
Expression system: Komagataella pastoris

Quick links

Citations

7 review citations

Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology.
Malavasi et al. (2008)
6 more

1 mention without citation

Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation.
Benton et al. (2021)