› 2o42

X-ray diffraction
2.91Å resolution

Crystal Structure of M11L, Bcl-2 homolog from myxoma virus

Released:
DOI: 10.2210/pdb2o42/pdb
PDB entry 2o42 coloured by chain, front view.
PDB entry 2o42 coloured by chain, side view.
PDB entry 2o42 coloured by chain, top view.
Source organism: Myxoma virus
Primary publication:
Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2.
Douglas AE, Corbett KD, Berger JM, McFadden G, Handel TM
Protein Sci 16 695-703 (2007)
PMID: 17384234

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis regulator M11L Chains: A, B
Molecule details ›
Chains: A, B
Length: 144 amino acids
Theoretical weight: 16.56 KDa
Source organism: Myxoma virus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q85295 (Residues: 1-142; Coverage: 86%)
Gene names: M11L, m011L
Sequence domains: Apoptosis regulator M11L like
Structure domains: Blc2-like

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 10 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P3121
Unit cell:
a: 73.151Å b: 73.151Å c: 186.875Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.251 0.249 0.29
Expression system: Escherichia coli

Quick links

Citations

20 review citations

The BCL-2 protein family: opposing activities that mediate cell death.
Youle et al. (2008)
19 more

6 mentions without citation

Poxvirus proteomics and virus-host protein interactions.
Van Vliet et al. (2009)
5 more