› 2o84

X-ray diffraction
2.6Å resolution

Crystal structure of K206E mutant of N-lobe human transferrin

Released:
DOI: 10.2210/pdb2o84/pdb
PDB entry 2o84 coloured by chain, front view.
PDB entry 2o84 coloured by chain, side view.
PDB entry 2o84 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of two mutants that probe the role in iron release of the dilysine pair in the N-lobe of human transferrin.
Baker HM, Nurizzo D, Mason AB, Baker EN
Acta Crystallogr D Biol Crystallogr 63 408-14 (2007)
PMID: 17327678

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotransferrin Chain: X
Molecule details ›
Chain: X
Length: 337 amino acids
Theoretical weight: 37.22 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt:
  • Canonical: P02787 (Residues: 20-356; Coverage: 50%)
Gene names: PRO1400, TF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand FE 1 x FE
Ligand CO3 1 x CO3
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 44.173Å b: 57.317Å c: 135.583Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.213 0.269
Expression system: Mesocricetus auratus

Quick links

Citations

1 review citation

Computational approaches for deciphering the equilibrium and kinetic properties of iron transport proteins.
Abdizadeh et al. (2017)
3 other articles