› 2odd

Solution NMR

Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor

Released:
DOI: 10.2210/pdb2odd/pdb
PDB entry 2odd coloured by chain, ensemble of 25 models, front view.
PDB entry 2odd coloured by chain, ensemble of 25 models, side view.
PDB entry 2odd coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.
Liu Y, Chen W, Gaudet J, Cheney MD, Roudaia L, Cierpicki T, Klet RC, Hartman K, Laue TM, Speck NA, Bushweller JH
Cancer Cell 11 483-97 (2007)
PMID: 17560331

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170348 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor corepressor 2 Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 1.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9Y618 (Residues: 1101-1113; Coverage: 1%)
Gene names: CTG26, NCOR2
Protein CBFA2T1 Chain: A
Molecule details ›
Chain: A
Length: 64 amino acids
Theoretical weight: 7.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q06455 (Residues: 510-559; Coverage: 8%)
Gene names: AML1T1, CBFA2T1, CDR, ETO, MTG8, RUNX1T1, ZMYND2
Sequence domains: MYND finger
Structure domains: Helix Hairpins

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

14 review citations

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers.
Taverna et al. (2007)
13 more

20 mentions without citation

Nuclear hormone receptor co-repressors: structure and function.
Watson et al. (2012)
19 more