› 2ofn

Solution NMR

Solution structure of FK506-binding domain (FKBD)of FKBP35 from Plasmodium falciparum

Released:
DOI: 10.2210/pdb2ofn/pdb
PDB entry 2ofn coloured by chain, ensemble of 20 models, front view.
PDB entry 2ofn coloured by chain, ensemble of 20 models, side view.
PDB entry 2ofn coloured by chain, ensemble of 20 models, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Solution structure of FK506 binding domain (FKBD) of Plasmodium falciparum FK506 binding protein 35 (PfFKBP35).
Kang CB, Ye H, Yoon HR, Yoon HS
Proteins 70 300-2 (2008)
PMID: 17876830

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184673 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase FKBP35 Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.36 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8I4V8 (Residues: 1-127; Coverage: 42%)
Gene names: FKBP35, PF3D7_1247400
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 citation in other articles

NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35.
Alag et al. (2010)
6 more

2 mentions without citation

Structural insights into Plasmodium PPIases.
Rajan et al. (2022)
1 more