› 2oi2

X-ray diffraction
2.5Å resolution

Streptococcus pneumoniae Mevalonate Kinase in Complex with Diphosphomevalonate

Released:
DOI: 10.2210/pdb2oi2/pdb
PDB entry 2oi2 coloured by chain, front view.
PDB entry 2oi2 coloured by chain, side view.
PDB entry 2oi2 coloured by chain, top view.
Source organism: Streptococcus pneumoniae
Primary publication:
Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate.
Andreassi JL, Bilder PW, Vetting MW, Roderick SL, Leyh TS
Protein Sci 16 983-9 (2007)
PMID: 17400916

Function and Biology Details

Reaction catalysed: 
ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-101407 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mevalonate kinase Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 31.46 KDa
Source organism: Streptococcus pneumoniae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A0H2UNK6 (Residues: 1-292; Coverage: 100%)
Gene names: SP_0381, mvaK1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand DP6 1 x DP6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3121
Unit cell:
a: 101.597Å b: 101.597Å c: 83.28Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.211 0.27
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Enzymes of the mevalonate pathway of isoprenoid biosynthesis.
Miziorko HM. (2011)
1 more

3 mentions without citation

Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate.
Andreassi et al. (2007)
2 more